Synthesis and characterization of the 7-(4-aminomethyl-1H-1,2,3-triazol-1-yl) analogue of kabiramide C.
نویسندگان
چکیده
The 7-(4-aminomethyl-1H-1,2,3-triazol-1-yl) analogue of kabiramide C (5) was synthesized by using the Mitsunobu reaction and 1,3-dipolar cycloaddition. This compound and the intermediate compounds 2 and 4 were shown to bind tightly to G-actin in a 1:1 complex and exhibited the same degree of cytotoxicity as 1. Compound 5 serves as a key intermediate for the synthesis of actin-directed optical probes and drugs.
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عنوان ژورنال:
- Journal of natural products
دوره 68 2 شماره
صفحات -
تاریخ انتشار 2005